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References:

1 Enhanced Antibacterial Activity of Cetylpyridinium chloride in Oil: Water Mixtures; O.Ilan and M.Rosenberg;Tel-Aviv University, Israel; Journal of Dental Research 75 (5) 1996

2 International Journal of Dental Hygiene 6; 2008; 290-303; Bacterial Desorption by Commercial Mouthwashes vs. Two Phase Oil: Water Formulations; S. Goldberg and M. Rosenberg; Tel-Aviv University; published Biofouling, Vol 3, p. 193-198 (1991)

3 Professor Seymour; data on file

4 Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005

5 2008 US independent laboratory trials

6 International Journal of Dental Hygiene 6; 2008; 290-303; Bacterial Desorption by Commercial Mouthwashes vs. Two Phase Oil: Water Formulations; S. Goldberg and M. Rosenberg; Tel-Aviv University; published Biofouling, Vol 3, p. 193-198 (1991). 2008 US independent laboratory trials. Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005; Bacterial desorption by commercial mouthwashes vs. two-phase oil: water formulations; S. Goldberg, M. Rosenberg; Biofouling, 1991, Vol 3, pp193-198.  Periodontology 2000, vol.48, 2008, 42-53pp.  Enhanced Antibacterial Activity of Cetylpyridinium chloride in Oil: Water Mixtures; O. Ilan and M. Rosenberg;  Tel-Aviv University, Israel. Journal of Dental Research 75 (5) 1996

7 International Journal of Dental Hygiene 6; 2008; 290-303

8 Bacterial Desorption By Commercial Mouthwashes vs. Two Phase Oil: Water Formulations; S. Goldberg and M. Rosenberg; Tel-Aviv University; published Biofouling, Vol 3, p. 193-198 (1991)
8 2008 US independent laboratory trials

9 Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005; Bacterial desorption by commercial mouthwashes vs. two-phase oil: water formulations; S.Goldberg, M.Rosenberg; Biofouling, 1991, Vol 3, pp193-198

10 Enhanced Antibacterial Activity of Cetylpyridinium chloride in Oil: Water Mixtures; O.Ilan and M. Rosenberg; Tel-Aviv University, Israel. Journal of Dental Research 75 (5) 1996

11 Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005

12 2008 US independent laboratory trials; Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005

13 Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005; Bacterial desorption by commercial mouthwashes vs two-phase oil: water formulations; S Goldberg, M Rosenberg; Biofouling, 1991, Vol 3, pp193-198

14 Professor Seymour; data on file

15 www.drinksdestroyteeth.com; eHow.com

16 Reference on file

17 2008 US independent laboratory trials; Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005

18 International Journal of Dental Hygiene 6; 2008; 290-303

19 Enhanced Antibacterial Activity of Cetylpyridinium chloride in Oil: Water Mixtures; O.Ilan and M.Rosenberg;Tel-Aviv University, Israel; Journal of Dental Research 75 (5) 1996

20 2008 US independent laboratory trials. Preliminary Investigation (Dentyl Mouthwash); The Lord Zuckerman Research Centre, Reading, UK; 3rd February 2005. J Periodontol 2006, 77, 1380-1385: Haps S, Slot DE, Berchier CE, Van der Weijden GA, The effect of Cetylpyridinium chloride as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review. Int J dent Hygiene, 2008, 6, 290-303. Bacterial Desorption by Commercial Mouthwashes vs. Two Phase Oil: Water Formulations; S. Goldberg and M. Rosenberg; Tel-Aviv University; published Biofouling, Vol 3, p. 193-198 (1991). 2008 US independent laboratory trials

21 J Periodontol 2006, 77, 1380-1385: Haps S, Slot DE, Berchier CE, Van der Weijden GA, The effect of Cetylpyridinium chloride as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review. Int J dent Hygiene, 2008, 6, 290-303. Bacterial Desorption by Commercial Mouthwashes vs. Two Phase Oil: Water Formulations; S. Goldberg and M. Rosenberg; Tel-Aviv University; published Biofouling, Vol 3, p. 193-198 (1991). 2008 US independent laboratory trials

22 2008 US independent laboratory trials

23 Marinho VC, Higgins JP, Logan S, Sheiham A: Fluoride mouthrinses for preventing dental caries in children and adolescents; Cochrane Database Syst  Rev 2003

24 Data on file; Effects of a two phased oil: water mouthwash on halitosis – Clinical Preventive Dentistry, Vol 14, No 1; Jan/Feb 1992

25 Temporary aqueous emulsions containing oil (n-hexadecane; 20% v/v) and CPC (0.05%) were applied to test tubes (N=4) and to crown sections of human teeth (N=8) and then poured off. The residual antibacterial activity was assayed by measuring the outgrowth of added suspensions of Escherlchla coll, as compared with appropriate controls. Control test tubes, to which either an aqueous solution of CPC alone or a water: oil mixture without CPC had been applied, exhibited little or no inhibitory effect (<3 hours). In contrast, test tubes containing the residue of the temporary emulsion with both CPC and oil inhibited outgrowth for 18 hours. Similarly, crown sections immersed in the CPC/oil emulsion inhibited outgrowth by 24%, as compared with 4% and 9% for the controls lacking either oil or CPC, respectively. Spectrophotometric measurements confirmed release of CPC from oil droplets over time. The results suggest that oil: water mixtures containing CPC enhance the activity of the antibacterial agent, presumably by prolonging its release over time. (Reference: O. Ilan and M. Rosenberg, Tel-Aiv University, Ramat Aviv, Israel); Hur MH, Park J, Maddock-Jennings W et al. Reduction of mouth malodour and volatile sulphur compounds in intensive care patients using an essential oil mouthwash; Phytother Res 2007 Jul;21(7):641-3.

26 Reference on file

27 National Statistics – 2003 Children’s Dental Health Survey (conducted every 10 yrs)

28 BCM consumer claims test June 2009; data on file

29 Data on file

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